Multiple evolutionary origins of bat papillomaviruses.

摘要: Infection by papillomaviruses (PVs) has been linked to different types of neoplasias, in both human and non-human hosts. Knowledge about PV diversity is essential reliably infer the evolutionary history these pathogens elucidate link between infection disease. We cloned sequenced complete genome a novel PV, EhelPV1, isolated from hair bulbs captive straw-colored fruit bat Eidolon helvum (Pteropodidae, Chiroptera). also retrieved partial sequences E1 L1 genes Indian flying fox Pteropus giganteus The detected virus (PgigPV1) presumably corresponded type as well. Maximum likelihood phylogenetic analyses were conducted using representative collection 132 PVs. EhelPV1 belonged Lambda+Mu-PV crown group was most closely related another MschPV2. Both fragments PgigPV1 placed alongside with EhelPV1. PVs phylogenetically distant other previously described PVs, namely MrPV1, MschPV1 RaPV1. have further characterized sequence patterns E2-binding sites occurring upstream regulatory region Lambda+Mu-PVs. Common fingerprints within this are shared certain However, there not sharp correspondence repertoire transcription factor binding viral host range, tissue tropism or life style. Our results reinforce hypothesis that undergone an initial radiation prior divergence mammalian hosts, giving rise present-day groups.