Identification of two novel equine papillomavirus sequences suggests three genera in one cluster.

摘要: The number of recognized papillomavirus (PV) species and potential PV genera has dramatically been increasing throughout the past decade. It seems that every host might potentially harbour a large set PVs, while PVs each appear to belong only few genera. In horses at least three conditions beside equine sarcoid have described, being supposedly induced namely classical papillomas, genital papillomas aural plaques. We were able identify DNA novel (EcPVs) in two latter disorders where involvement had predicted. Both genomes entirely cloned sequenced. EcPV genomes, one derived from penile papilloma, other an ear papilloma contain characteristic open reading frames (ORFs) E6, E7, E1, E2, L2 L1, non-coding region between late early as well small region. viruses consequently designated EcPV2 EcPV3. analysed compared with further PVs. Upon phylogenetic analyses group together. Pairwise alignment L1 nucleotide sequences reveals EcPV1 shares 54.9% identities 53.2% EcPV3 share 51.3% identities. As EcPVs less than 60% they may be regarded belonging different