Targeting miR-148b-5p Inhibits Immunity Microenvironment and Gastric Cancer Progression.
作者： Xin Jiang , Yuyu Zhang , Chao Qu , Jinlong Wei , Bin Wang
DOI: 10.3389/FIMMU.2021.590447
关键词:
摘要: Background MicroRNAs (miRNAs) have been discovered to dictate the development of various tumors. However, studies on roles miRNAs in progression gastric cancer (GC) are still lacking. Methods Herein, by analyzing GC cell lines and patients samples, we observed that miR-148b-5p was significantly downregulated GC. We also confirmed overexpression inhibited proliferation invasion vitro vivo. Results Overexpression not only reprogrammed metabolic properties but regulated immune microenvironment shifting lymphocyte myeloid populations. Mechanistically, ATPIF1, an important glycolysis-associated gene, identified as a direct target mediated effect miR-148b-5p. Notably, low level related with poor prognosis (P < 0.001). Importantly, levels changed sensitivity cells several anti-cancer drugs (Doxorubicin, P 0.05, Paclitaxel, 0.01, Docetaxel, 0.05). Conclusions Targeting inhibits immunity progression.
frontiersin.org
sci-hub.st 参考文章(25)
Eric A. Benson, Todd C. Skaar, Yunlong Liu, Kenneth P. Nephew, Daniela Matei, Carboplatin with Decitabine Therapy, in Recurrent Platinum Resistant Ovarian Cancer, Alters Circulating miRNAs Concentrations: A Pilot Study PLOS ONE. ,vol. 10, pp. e0141279- ,(2015) , 10.1371/JOURNAL.PONE.0141279
F J Kohlhapp, A K Mitra, E Lengyel, M E Peter, MicroRNAs as mediators and communicators between cancer cells and the tumor microenvironment. Oncogene. ,vol. 34, pp. 5857- 5868 ,(2015) , 10.1038/ONC.2015.89
Ling Shan, Jianming Ying, Ning Lu, HER2 expression and relevant clinicopathological features in gastric and gastroesophageal junction adenocarcinoma in a Chinese population. Diagnostic Pathology. ,vol. 8, pp. 76- 76 ,(2013) , 10.1186/1746-1596-8-76
Ruipeng Song, Huiwen Song, Yingjian Liang, Dalong Yin, Heng Zhang, Tongsen Zheng, Jiabei Wang, Zhaoyang Lu, Xuan Song, Tiemin Pei, Youyou Qin, Yuejin Li, Changming Xie, Boshi Sun, Huawen Shi, Shuai Li, Xianzhi Meng, Guangchao Yang, Shangha Pan, Jiyuan Zhu, Shuyi Qi, Hongchi Jiang, Zhiyong Zhang, Lianxin Liu, Reciprocal activation between ATPase inhibitory factor 1 and NF‐κB drives hepatocellular carcinoma angiogenesis and metastasis Hepatology. ,vol. 60, pp. 1659- 1673 ,(2014) , 10.1002/HEP.27312
Ivana Matic, Stefania Cocco, Caterina Ferraina, Rebeca Martin-Jimenez, Fulvio Florenzano, James Crosby, Ramona Lupi, Giusy Amadoro, Claire Russell, Giuseppe Pignataro, Lucio Annunziato, Andrey Y. Abramov, Michelangelo Campanella, Neuroprotective coordination of cell mitophagy by the ATPase Inhibitory Factor 1. Pharmacological Research. ,vol. 103, pp. 56- 68 ,(2016) , 10.1016/J.PHRS.2015.10.010
Heng Zhang, Xiaofeng Guo, Xing Feng, Tingting Wang, Zhaohua Hu, Xiangyong Que, Qingsong Tian, Tianbo Zhu, Guixian Guo, Wei Huang, Xinzhi Li, MiRNA-543 promotes osteosarcoma cell proliferation and glycolysis by partially suppressing PRMT9 and stabilizing HIF-1α protein. Oncotarget. ,vol. 8, pp. 2342- 2355 ,(2017) , 10.18632/ONCOTARGET.13672
Ángela Riffo-Campos, Ismael Riquelme, Priscilla Brebi-Mieville, Tools for Sequence-Based miRNA Target Prediction: What to Choose? International Journal of Molecular Sciences. ,vol. 17, pp. 1987- ,(2016) , 10.3390/IJMS17121987
De He, Cheng Huang, Qingxin Zhou, Dawei Liu, Longhui Xiong, Hongxia Xiang, Guangnian Ma, Zhiyong Zhang, HnRNPK/miR-223/FBXW7 feedback cascade promotes pancreatic cancer cell growth and invasion Oncotarget. ,vol. 8, pp. 20165- 20178 ,(2017) , 10.18632/ONCOTARGET.15529
Penn Muluhngwi, Negin Alizadeh-Rad, Stephany L. Vittitow, Ted S. Kalbfleisch, Carolyn M. Klinge, The miR-29 transcriptome in endocrine-sensitive and resistant breast cancer cells. Scientific Reports. ,vol. 7, pp. 5205- 5205 ,(2017) , 10.1038/S41598-017-05727-W
René G. Feichtinger, Daniel Neureiter, Tom Skaria, Silja Wessler, Timothy L. Cover, Johannes A. Mayr, Franz A. Zimmermann, Gernot Posselt, Wolfgang Sperl, Barbara Kofler, Oxidative Phosphorylation System in Gastric Carcinomas and Gastritis Oxidative Medicine and Cellular Longevity. ,vol. 2017, pp. 1320241- 1320241 ,(2017) , 10.1155/2017/1320241