The relative contributions of tubular reabsorption and secretion to urate excretion in lead nephropathy.

摘要: Summary: Renal tubular reabsorption and secretion of urate have been separately assessed in patients with lead nephropathy by observation the effect on renal disposition drug pyrazinamide, which blocks active urate. Tubular was found to be greater than expected for degree failure as reflected inulin clearance, whereas within range predicted from plasma concentration. As hypewricaemia has shown origin, these results suggest that it is mediated excessive Though defective not demonstrated, more extensive studies over a wide concentrations would needed exclude an additional associated abnormality secretory process. Copyright