Computational approaches for drug repositioning and combination therapy design.

作者: EKATERINA KOTELNIKOVA , ANTON YURYEV , ILYA MAZO , NIKOLAI DARASELIA

DOI: 10.1142/S0219720010004732

关键词:

摘要: Heterogeneous high-throughput biological data become readily available for various diseases. The amount of points generated by such experiments does not allow manual integration the informa...

参考文章(30)
G. Bunone, P. A. Briand, R. J. Miksicek, D. Picard, Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. The EMBO Journal. ,vol. 15, pp. 2174- 2183 ,(1996) , 10.1002/J.1460-2075.1996.TB00571.X
Anton Yuryev, Zufar Mulyukov, Ekaterina Kotelnikova, Sergei Maslov, Sergei Egorov, Alexander Nikitin, Nikolai Daraselia, Ilya Mazo, Automatic pathway building in biological association networks. BMC Bioinformatics. ,vol. 7, pp. 171- 171 ,(2006) , 10.1186/1471-2105-7-171
Manfred Kunz, Steffen Moeller, Dirk Koczan, Peter Lorenz, Roland H. Wenger, Michael O. Glocker, Hans-Juergen Thiesen, Gerd Gross, Saleh M. Ibrahim, Mechanisms of hypoxic gene regulation of angiogenesis factor Cyr61 in melanoma cells. Journal of Biological Chemistry. ,vol. 278, pp. 45651- 45660 ,(2003) , 10.1074/JBC.M301373200
Dong Xie, Dong Yin, Xiangjun Tong, James O’Kelly, Akio Mori, Carl Miller, Keith Black, Dorina Gui, Johathan W. Said, H. Phillip Koeffler, Cyr61 Is Overexpressed in Gliomas and Involved in Integrin-Linked Kinase-Mediated Akt and β-Catenin-TCF/Lef Signaling Pathways Cancer Research. ,vol. 64, pp. 1987- 1996 ,(2004) , 10.1158/0008-5472.CAN-03-0666
Jing Fang, Sai-Juan Chen, Jian-Hua Tong, Zhu-Gang Wang, Guo-Qiang Chen and, Treatment of acute promyelocytic leukemia with ATRA and As2O3: a model of molecular target-based cancer therapy. Cancer Biology & Therapy. ,vol. 1, pp. 614- 620 ,(2002) , 10.4161/CBT.308
Yang Jin, Hong Pyo Kim, Emeka Ifedigbo, Lester F. Lau, Augustine M. K. Choi, Cyr61 protects against hyperoxia-induced cell death via Akt pathway in pulmonary epithelial cells. American Journal of Respiratory Cell and Molecular Biology. ,vol. 33, pp. 297- 302 ,(2005) , 10.1165/RCMB.2005-0144OC
A. M. Babic, M. L. Kireeva, T. V. Kolesnikova, L. F. Lau, CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 6355- 6360 ,(1998) , 10.1073/PNAS.95.11.6355
J. Tuettenberg, C. Friedel, P. Vajkoczy, Angiogenesis in malignant glioma—A target for antitumor therapy? Critical Reviews in Oncology Hematology. ,vol. 59, pp. 181- 193 ,(2006) , 10.1016/J.CRITREVONC.2006.01.004
Anton Yuryev, Ekaterina Kotelnikova, Nikolai Daraselia, Ariadne's ChemEffect and Pathway Studio knowledge base Expert Opinion on Drug Discovery. ,vol. 4, pp. 1307- 1318 ,(2009) , 10.1517/17460440903413488