Modeling Hypoxia-Induced Seizures and Hypoxic Encephalopathy in Developing Brain

摘要: The neonatal period represents one of the highest incidence periods for seizures across lifespan. Hypoxic and/or ischemic encephalopathy is most common cause seizures, and accounts more than two-thirds seizure cases. Patients with are often refractory to conventional antiepileptic drugs, can result in later life epilepsy cognitive deficits, conditions which there no specific treatments. A better understanding cellular molecular mechanisms essential identifying new therapeutic strategies that control its long-term comorbidities. In this regard, animal models play an role discovering novel underlying both epileptogenesis associated To date, a number have made tremendous progress our pathophysiology HIE-induced seizures. This chapter provides overview on important features main hypoxia-induced developing brain. particular, we focus methodology induction characterizations postseizure consequences. These aspects discussed light suitability these studying human