Models of hypoxia and ischemia-induced seizures.

摘要: Despite greater understanding and improved management, seizures continue to be a major problem in childhood. Neonatal are often refractory conventional antiepileptic drugs, can result later life epilepsy cognitive deficits, conditions for which there no specific treatments. Hypoxic and/or ischemic encephalopathy (HIE) is the most common cause neonatal seizures, accounts more than two-thirds of seizure cases. A better cellular molecular mechanisms essential identifying new therapeutic strategies that control its consequences. This heavily relies on animal models play critical role discovering novel underlying both epileptogenesis associated impairments. To date, number have provided tremendous amount information regarding pathophysiology HIE-induced seizures. review provides an overview important features main In particular, we focus methodology induction characterizations post-HIE injury These aspects discussed light suitability these studying human