Neonatal Seizure Models to Study Epileptogenesis.

摘要: Current therapeutic strategies for epilepsy include anti-epileptic drugs and surgical treatments that are mainly focused on the suppression of existing seizures rather than occurrence first spontaneous seizure. These symptomatic help a certain proportion patients, but these not intended to clarify cellular molecular mechanisms underlying primary process development, i.e., epileptogenesis. Epileptogenic changes reorganization neural glial circuits, resulting in formation an epileptogenic focus. To achieve goal developing “anti-epileptogenic” drugs, we need step-by-step epileptogenesis patients whose controllable with “anti-epileptic” drugs. Epileptogenesis has been studied using animal models neonatal because such useful studying latent period before lowering seizure threshold. Further, generally easy handle can be applied vitro studies cells brain suitable culture. Here, review two discuss their features, specifically focusing hypoxia–ischemia-induced febrile seizures. Studying will contribute identifying potential targets biomarkers