Iron Deficiency Affects Seizure Susceptibility in a Time- and Sex-Specific Manner:

摘要: Iron deficiency (ID) affects more than three billion people worldwide making it the most common micronutrient deficiency. ID is prevalent during gestation and early life, which of particular concern since its impact on developing central nervous system associated with an increased risk a wide range different psychiatric disorders later in life. The cause for this association not known, but many these same are also imbalance between excitation inhibition (E/I) within brain. Based shared impairment, we asked whether could contribute to such imbalance. Disruptions E/I balance can be uncovered by brain’s response seizure inducing insults. We therefore tested threshold under nutritional models ID. found that mice were postnatally exposed (and acutely ID) had decreased susceptibility certain types. In contrast, expose...