The effect of porcine ADM to improve the burn wound healing
作者： Shubin Ruan , Zepeng Lin , Julin Xie , Bin Shu , Rui Shen
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摘要: To study the effect of porcine acellular dermal matrix (ADM) on burn wound healing. Seventy healthy Wistar rats were inflicted with 2 cm second degree and divided into groups; one group was treated ADM other Povidone Iodine Cream. Biopsies taken day 1, 3, 5, 7, 10, 14, 21 for histopathological biochemical analysis to test PCNA, K19, Integrin-β1, PDGF, EGF FGF. The results revealed relatively better faster regeneration after treatment ADM, along greatly increased synthesis in collagen experimental group. Integrin-β1 had an increase then tapered down, stronger than contrast during days burns. FGF levels peaked 5 started decrease, while significantly enhanced expression relevant growth factors observed Porcine stimulate synthesis, stem cells proliferation differentiation, ultimately improve
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