The Drosophila BTB Domain Protein Jim Lovell Has Roles in Multiple Larval and Adult Behaviors

摘要: Innate behaviors have their origins in the specification of neural fates during development. Within Drosophila, BTB (Bric-a-brac,Tramtrack, Broad) domain proteins such as Fruitless are known to play key roles differentiation underlying responses. We previously identified a gene, which we termed jim lovell (lov), encoding protein with role gravity To understand more fully behavioral this gene investigated its function through several approaches. Transcript and expression patterns been examined phenotypes new lov mutations characterized. Lov is nuclear protein, suggesting transcriptional regulator, for other proteins. In late embryogenesis, expressed many CNS PNS neurons. An examination indicates that functions classes sensory particular, only two five abdominal lateral chordotonal neurons express Lov, predicting functional variation within highly similar group. Surprisingly, also very early embryogenesis ways suggests morphogenetic movements, amnioserosa head neurogenesis. The delete adjacent non-coding DNA regions strikingly different removal regulatory elements. lov47, lost embryonic including lov47 mutant larvae show feeding locomotor defects spontaneous backward movement. Adult males perform aberrant courtship behavior distinguished by displays not directed at female. adults defective negative gravitaxis than isolated lov91Y mutant. contrast, lov66 produces largely normal but severe female sterility associated ectopic ovary. propose deleted lov66.