Detecting the earliest signs of rheumatoid arthritis: symptoms and examination.

摘要: Signs and symptoms often occur well in advance of a formal diagnosis rheumatoid arthritis (RA). However, these do not necessarily represent that are included classification criteria. Their intensity, frequency, persistence over time seem to be important the spectrum from preclinical autoimmunity classifiable RA. Prospective study signs individuals at risk for RA will help determine their onset relationship with epitope spreading, cytokine evolution, sensitive imaging, usefulness discriminating between patients who develop incident inflammatory versus normal controls.