The Alere BinaxNOW Pneumococcal Urinary Antigen Test: Diagnostic Sensitivity for Adult Pneumococcal Pneumonia and Relationship to Specific Serotypes.

摘要: Little is known about the sensitivity of BinaxNOW pneumococcal urinary antigen (PUA) test for adult pneumonia caused by different serotypes. In this study, we aimed to analyze trends in PUA over a 15-year period (2001 2015) and its total, analyzed 1,096 isolates from adults with who had performed at onset episode. Three periods were analyzed: 2001 2005 (early use seven-valent conjugate vaccine [early PCV7]), 2006 2010 (late PCV7), 2011 2015 PCV13). The varied 76.4% (95% confidence interval [CI], 70.5% 82.4%) 77.9% CI, 74.4% 81.4%) decreased 60.5% 55.4% 65.6%) 2015. This decrease was observed 560 proven (83.2% 2005, 86.5% 2010, 78.1%) 536 probable (70.0% 68.7% 41.5% episodes pneumonia. Differences diagnosing certain serotypes, being highest 9V (90.6%), 14 (86.8%), 18C (100%), 20 (100%) serotypes lowest 8 (55.2%), 9L/N (39.1%), 11A (48.8%), 23B (33.3%), nontypeable (47.8%) Comparing 2015, prevalence (3.1%, 3.7%, 1.7%, respectively) (7.2%, 5.1%, 3.1%, decreased, while (0%, 0.7%, 1.4%, respectively), (1.0%, 1.6%, 3.4%, (2.6%, 4.2%, (1.5%, 1.5%, increased. serotype, these differences changes serotype distribution associated an overall test.