Effects of basal insulin application on serum visfatin and adiponectin levels in type 2 diabetes
作者： WEI-DONG WANG , LIN XING , JUN-RU TENG , SHUO LI , NA MI
关键词:
摘要: The aim of this study was to investigate the effects basal insulin application on serum visfatin and adiponectin (APN) levels patients with type 2 diabetes mellitus (T2DM). A total 200 T2DM, who were diagnosed in Third People's Hospital Jinan (glycosylated hemoglobin ≥7%), randomly divided into treatment control groups. used only oral hypoglycemic drugs had never received therapy. In group, administered combination original drugs, whereas group maintained use or took other agents. body mass index fasting blood glucose, postprandial glycosylated hemoglobin, visfatin, APN lipid examined prior six months later. drug doses adjusted according patients' which allowed glucose attain standards. also achieved It found that six-month could significantly decrease increase levels; levels, however, remained unchanged. immediate facilitate attainment standards T2DM plasma preventing diabetic vascular complications.
sci-hub.se 参考文章(47)
B. Fagerberg, D. Kellis, G. Bergström, C. J. Behre, Adiponectin in relation to insulin sensitivity and insulin secretion in the development of type 2 diabetes: a prospective study in 64-year-old women Journal of Internal Medicine. ,vol. 269, pp. 636- 643 ,(2011) , 10.1111/J.1365-2796.2010.02336.X
Cia-Hin Lau, Sekaran Muniandy, Adiponectin and resistin gene polymorphisms in association with their respective adipokine levels. Annals of Human Genetics. ,vol. 75, pp. 370- 382 ,(2011) , 10.1111/J.1469-1809.2010.00635.X
C. Hug, MEDICINE: Visfatin: A New Adipokine Science. ,vol. 307, pp. 366- 367 ,(2005) , 10.1126/SCIENCE.1106933
Gábor Winkler, Károly Cseh, Molecular mechanisms of insulin resistance in obesity and type 2 diabetes mellitus Orvosi Hetilap. ,vol. 150, pp. 771- 780 ,(2009) , 10.1556/OH.2009.28608
Wing Tak Wong, Xiao Yu Tian, Aimin Xu, Jun Yu, Chi Wai Lau, Ruby L.C. Hoo, Yu Wang, Vivian W.Y. Lee, Karen S.L. Lam, Paul M. Vanhoutte, Yu Huang, Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice Cell Metabolism. ,vol. 14, pp. 104- 115 ,(2011) , 10.1016/J.CMET.2011.05.009
H. Yki-Järvinen, R. Kauppinen-Mäkelin, M. Tiikkainen, M. Vähätalo, H. Virtamo, K. Nikkilä, T. Tulokas, S. Hulme, K. Hardy, S. McNulty, J. Hänninen, H. Levänen, S. Lahdenperä, R. Lehtonen, L. Ryysy, Insulin glargine or NPH combined with metformin in type 2 diabetes: the LANMET study. Diabetologia. ,vol. 49, pp. 442- 451 ,(2006) , 10.1007/S00125-005-0132-0
Stig S. Frøland, Kirsten Krohg-Sørensen, David Russell, Pål Aukrust, Bente Halvorsen, Tuva B. Dahl, Arne Yndestad, Mona Skjelland, Erik Øie, Arve Dahl, Annika Michelsen, Jan K. Damås, Siv H. Tunheim, Thor Ueland, Camilla Smith, Bjørn Bendz, Serena Tonstad, Lars Gullestad, Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: possible role in inflammation and plaque destabilization. Circulation. ,vol. 115, pp. 972- 980 ,(2007) , 10.1161/CIRCULATIONAHA.106.665893
Sheng-Chiang Su, Dee Pei, Chang-Hsun Hsieh, Fone-Ching Hsiao, Chung-Ze Wu, Yi-Jen Hung, Circulating pro-inflammatory cytokines and adiponectin in young men with type 2 diabetes. Acta Diabetologica. ,vol. 48, pp. 113- 119 ,(2011) , 10.1007/S00592-009-0171-Y
NG Forouhi, N Sattar, PM McKeigue, Relation of C-reactive protein to body fat distribution and features of the metabolic syndrome in Europeans and South Asians. International Journal of Obesity. ,vol. 25, pp. 1327- 1331 ,(2001) , 10.1038/SJ.IJO.0801723
J. C. Pickup, Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care. ,vol. 27, pp. 813- 823 ,(2004) , 10.2337/DIACARE.27.3.813