Preparation and retention behaviour of chemically bonded methylated-cyclodextrin stationary phases for liquid chromatography

摘要: Abstract Both α-and β-cyclodextrinwere converted into the ethylenediamine monosubstituted per-O-methyl derivatives, and latter were coupled to succinamidopropyl silica. The resulting methylated α-cyclodextrinstationary phase improves separation of ortho , meta para isomers several disubstituted benzene compared with unmodified α-cyclodextrin stationary phase. Methylation β-cyclodextrin, however, results in less good selectivity three isomers. β-cyclodextrin can efficiently separate antiepileptic drugs or substituted naphthalene derivatives.