Methylated cyclodextrin-bonded stationary phases for liquid chromatography

摘要: Abstract Ethylenediamine-monosubstituted per-O-methyl-α- and -β-cyclodextrin were coupled to succinamidopropyl silica. The unreacted, terminal carboxyl groups of the resulting methylated cyclodextrin stationary phases do not interact significantly with several disubstituted benzene derivatives having various functional groups. However, secondary amino —NH— group in spacer arm linking units silica gel interacts strongly solutes small pKa values, such as aminobenzoic nitrobenzoic acids. Methylated α-cyclodextrin non-nitrogen-containing arms prepared by reaction bare two organotrichlorosilanes incorporating α-cyclodextrin. These new exhibit strong interaction benzoic