The in vivo increase of factor VIII activity by 2,3-diphosphoglycerate
作者： Panayotis G. Iatridis , Sotirios G. Iatridis , Barth H. Ragatz
DOI: 10.1016/0049-3848(76)90101-8
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摘要: Abstract When 2,3-Diphosphoglycerate (2,3-DPG) was injected intravenously into rats, factor VIII (antihemophilic factor) procoagulant activity substantially increased. These effects are in accordance with what has been observed hemolytic anemias and after intravenous injection of hemolysed blood. 2,3-DPG did not inhibit nor enhance any other clotting vivo . In vitro change activity, indicating that the increase VIII, injection, is due to an activation, but rather a de novo release and/or synthesis or decrease catabolism VIII.
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