CARDIOPROTECTIVE ACTIVITY OF GARCINIA INDICA LINN. FRUIT EXTRACT ON ISOPRENALINE HYDROCHLORIDE INDUCED CARDIO TOXICITY IN RATS
作者： N. G. P Arts
DOI:
关键词:
摘要: Objective: The present study was undertaken to investigate the cardioprotective effect of ethanolic extract Garcinia indica linn fruit. Methods: were studied for their on isoprenaline hydrochloride (25mg/kg. b.w.) induced cardio toxicity wistar albino rats. degree protection measured by assessing biochemical parameters such as AST, ALT, LDH, CPK, CK-MB in serum and heart tissue homogenate membrane bound ATPase (Na+K+ ATPase, Mg2+ Ca2+ ATPase) homogenate. Results: at a dose 250mg/kg b.w., 500mg/kg b.w. produced significant (p<0.005) protective activities group III IV rats when compared (group II). Conclusion: Finally we concluded that fruit exerts equipotent activity experimental model myocardial necrosis
ijppsjournal.com参考文章(17)
Shu-Er Chow, Jan-Kan Chen, Antioxidants and myocardial ischemia: reperfusion injuries. Chang Gung medical journal. ,vol. 28, pp. 369- ,(2005)
John King, Practical Clinical Enzymology ,(1965)
Ithayarasi A Paritha, Devi Cs Shyamala, EFFECT OF ALPHA -TOCOPHEROL ON ISOPROTERENOL-INDUCED CHANGES IN LIPID AND LIPOPROTEIN PROFILE IN RATS Indian Journal of Pharmacology. ,vol. 29, pp. 399- 404 ,(1997)
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Pavel Hamet, The Evaluation of the Scientific Evidence for a Relationship between Calcium and Hypertension Journal of Nutrition. ,vol. 125, ,(1995) , 10.1093/JN/125.SUPPL_2.311S
Vishal R. Mali, Subhash L. Bodhankar, Cardioprotective effect of Lagenaria siceraria (LS) fruit powder in isoprenalin-induced cardiotoxicity in rats European Journal of Integrative Medicine. ,vol. 2, pp. 143- 149 ,(2010) , 10.1016/J.EUJIM.2010.03.003
S. OKINAKA, Serum creatine phosphokinase. Activity in progressive muscular dystrophy and neuromuscular diseases. JAMA Neurology. ,vol. 4, pp. 520- 525 ,(1961) , 10.1001/ARCHNEUR.1961.00450110050006
A. Vajreswari, K. Narayanareddy, Effect of dietary fats on some membrane-bound enzyme activities, membrane lipid composition and fatty acid profiles of rat heart sarcolemma. Lipids. ,vol. 27, pp. 339- 343 ,(1992) , 10.1007/BF02536147
Gyula Varadi, Yasuo Mori, Gabor Mikala, Arnold Schwartz, Molecular determinants of Ca2+ channel function and drug action Trends in Pharmacological Sciences. ,vol. 16, pp. 43- 49 ,(1995) , 10.1016/S0165-6147(00)88977-4
M. Martínez-Cayuela, Oxygen free radicals and human disease. Biochimie. ,vol. 77, pp. 147- 161 ,(1995) , 10.1016/0300-9084(96)88119-3