Cardioprotective effect of Lagenaria siceraria (LS) fruit powder in isoprenalin-induced cardiotoxicity in rats
作者： Vishal R. Mali , Subhash L. Bodhankar
DOI: 10.1016/J.EUJIM.2010.03.003
关键词:
摘要: Abstract Aim of study The objective the was to evaluate cardioprotective activity Lagenaria siceraria (LS) fruit powder in isoprenalin (ISO) induced cardiotoxicity rats. Material and methods Male Wistar rats (200–230 g) were divided into four groups. Grp I: control, II: (5.25 mg/kg, s.c. on day 50th 8.5 mg/kg 51th), III: LS (500 mg/kg, p.o.) suspended gum accacia (2%) for 49 days IV: 51 days. On 0 52nd blood withdrawn by retro-orbital puncture estimation marker enzymes. Haemodynamic parameters recorded. Animals sacrificed histology vital organs performed. Results Isoprenalin showed cardiotoxicity, manifested increase heart rate serum enzyme. alone produced bradycardia. In pretreated neither increased nor hypotensive effect. histopathology myocardial damage isoprenalin, lower LS + ISO Conclusion It has been concluded that (500 mg/kg) pretreatment protects isoprenalin-induced cardiotoxicity.
elsevier.com
sci-hub.se 参考文章(29)
BV Ghule, MH Ghante, AB Upaganlawar, PG Yeole, None, Analgesic and Anti-Inflammatory activities of Lagenaria siceraria Stand. fruit juice extract in rats and mice Pharmacognosy Magazine. ,vol. 2, pp. 232- ,(2006)
H. Gerhard Vogel, Drug Discovery and Evaluation: Pharmacological Assays ,(1997)
BV Ghule, MH Ghante, PG Yeole, AN Saoji, Diuretic activity of Lagenaria siceraria fruit extracts in rats Indian Journal of Pharmaceutical Sciences. ,vol. 69, pp. 817- 819 ,(2007) , 10.4103/0250-474X.39441
Ipseeta Mohanty, Suresh Kumar Gupta, Keval Krishan Talwar, Amit Dinda, Sujata Joshi, Pankaj Bansal, Amit Saxena, Dharamvir Singh Arya, Cardioprotection from ischemia and reperfusion injury by Withania somnifera: a hemodynamic, biochemical and histopathological assessment. Molecular and Cellular Biochemistry. ,vol. 260, pp. 39- 47 ,(2004) , 10.1023/B:MCBI.0000026051.16803.03
P.T. Devika, P. Stanely Mainzen Prince, Protective effect of (-)-epigallocatechin-gallate (EGCG) on lipid peroxide metabolism in isoproterenol induced myocardial infarction in male Wistar rats: a histopathological study. Biomedicine & Pharmacotherapy. ,vol. 62, pp. 701- 708 ,(2008) , 10.1016/J.BIOPHA.2007.10.011
M. Hassanpour, S.L. Bodhankar, Madhumira Dikshit, Cardioprotective Activity of Fruit of Lagenaria siceraria (Molina) Standley on Doxorubicin Induced Cardiotoxicity in Rats International Journal of Pharmacology. ,vol. 4, pp. 466- 471 ,(2008) , 10.3923/IJP.2008.466.471
P. R. Enslin, C. W. Holzapfel, K. Barbara Norton, S. Rehm, Bitter principles of the Cucurbitaceae. Part XV. Cucurbitacins from a hybrid of Lagenaria siceraria Journal of The Chemical Society C: Organic. pp. 964- 972 ,(1967) , 10.1039/J39670000964
Prashee A. Peer, Purvi C. Trivedi, Prashant B. Nigade, Mahesh M. Ghaisas, Avinash D. Deshpande, Cardioprotective effect of Azadirachta indica A. Juss. on isoprenaline induced myocardial infarction in rats International Journal of Cardiology. ,vol. 126, pp. 123- 126 ,(2008) , 10.1016/J.IJCARD.2007.01.108
Mukesh Nandave, Ipseeta Mohanty, TC Nag, Shreesh Kumar Ojha, Rajan Mittal, Santosh Kumari, Dharamvir Singh Arya, None, Cardioprotective response to chronic administration of vitamin E in isoproterenol induced myocardial necrosis: Hemodynamic, biochemical and ultrastructural studies Indian Journal of Clinical Biochemistry. ,vol. 22, pp. 22- 28 ,(2007) , 10.1007/BF02912876
Chiy-Rong Chen, Hung-Wei Chen, Chi-I Chang, D:C-friedooleanane-type triterpenoids from Lagenaria siceraria and their cytotoxic activity. Chemical & Pharmaceutical Bulletin. ,vol. 56, pp. 385- 388 ,(2008) , 10.1248/CPB.56.385