Cardioprotective effects induced by hydroalcoholic extract of leaves of Alpinia zerumbet on myocardial infarction in rats
作者： Emanuel Tenório Paulino , Amanda Karine Barros Ferreira , Jessyka Carolina Galvão da Silva , Cintia Danielli Ferreira Costa , Salete Smaniotto
DOI: 10.1016/J.JEP.2019.112037
关键词:
摘要: Abstract Ethnopharmacology relevance The leaves of Alpinia zerumbet is used in folk medicine Brazil to treat hypertension. However, the cardioprotective effect this plant has not been studied yet. Aim study To evaluate effects hydroalcoholic extract (AZE) against isoproterenol (ISO)-induced myocardial infarction rats. Material and methods Rats were pretreated orally with AZE (300 mg/kg) for 30 days prior ISO-induced infarction. rats sacrificed hearts collected homogenized biochemical analysis. At end experiment, cardiac marker enzyme levels, histological morphometric parameters, hemodynamic measurements assessed. Phytochemical compounds verified by gas chromatography-mass spectrometry (GC-MS). Results administered ISO showed a significant increase enzymes, i.e., creatine kinase-NAC (CK-NAC) CK-MB. Triphenyltetrazolium chloride (TTC) staining exhibited an infarct areas. In animals treated induced heart rate. Pretreatment significantly inhibited these ISO. Moreover, findings supported histopathological observations. GC-MS analyses identified volatile oils, kavalactones, phytosterols. Conclusions Haemodynamic, alteration results suggest protective oral administration cardiotoxicity.
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sci-hub.se 参考文章(35)
Chester H Conrad, Wesley W Brooks, Isoproterenol-Induced Myocardial Injury and Diastolic Dysfunction in Mice: Structural and Functional Correlates Comparative Medicine. ,vol. 59, pp. 339- 343 ,(2009)
Brent A. French, Christopher M. Kramer, Mechanisms of Post-Infarct Left Ventricular Remodeling. Drug Discovery Today: Disease Mechanisms. ,vol. 4, pp. 185- 196 ,(2007) , 10.1016/J.DDMEC.2007.12.006
Kunchupillai Lakshmanan Hemalatha, Ponnian Stanely Mainzen Prince, A biochemical and 2, 3, 5-triphenyl tetrazolium chloride staining study on the preventive effects of zingerone (vanillyl acetone) in experimentally induced myocardial infarcted rats. European Journal of Pharmacology. ,vol. 746, pp. 198- 205 ,(2015) , 10.1016/J.EJPHAR.2014.10.057
Lucas Liaudet, Belinda Calderari, Pal Pacher, Pathophysiological mechanisms of catecholamine and cocaine-mediated cardiotoxicity Heart Failure Reviews. ,vol. 19, pp. 815- 824 ,(2014) , 10.1007/S10741-014-9418-Y
Vishal R. Mali, Subhash L. Bodhankar, Cardioprotective effect of Lagenaria siceraria (LS) fruit powder in isoprenalin-induced cardiotoxicity in rats European Journal of Integrative Medicine. ,vol. 2, pp. 143- 149 ,(2010) , 10.1016/J.EUJIM.2010.03.003
D. Hansi Priscilla, P. Stanely Mainzen Prince, Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats. Chemico-Biological Interactions. ,vol. 179, pp. 118- 124 ,(2009) , 10.1016/J.CBI.2008.12.012
W. Kubler, M. Haass, Cardioprotection: definition, classification, and fundamental principles. Heart. ,vol. 75, pp. 330- 333 ,(1996) , 10.1136/HRT.75.4.330
David J. Whellan, Heart failure disease management: implementation and outcomes. Cardiology in Review. ,vol. 13, pp. 231- 239 ,(2005) , 10.1097/01.CRD.0000135765.60824.2F
P R Puleo, P A Guadagno, R Roberts, M V Scheel, A J Marian, D Churchill, M B Perryman, Early diagnosis of acute myocardial infarction based on assay for subforms of creatine kinase-MB. Circulation. ,vol. 82, pp. 759- 764 ,(1990) , 10.1161/01.CIR.82.3.759
Ponnian Stanely Mainzen Prince, Selvaraju Suman, Periyathambi Thangappan Devika, Muthukumarasamy Vaithianathan, Cardioprotective effect of 'Marutham' a polyherbal formulation on isoproterenol induced myocardial infarction in Wistar rats. Fitoterapia. ,vol. 79, pp. 433- 438 ,(2008) , 10.1016/J.FITOTE.2008.01.009