Differential Effects of Inflammation on Bone and Response to Biologics in Rheumatoid Arthritis and Spondyloarthritis
作者： Zheni Stavre , Katherine Upchurch , Jonathan Kay , Ellen M. Gravallese
DOI: 10.1007/S11926-016-0620-X
关键词:
摘要: We review the pathways, cytokines, and concepts important to pathogenesis of bone resorption formation in rheumatoid arthritis (RA) spondyloarthritis (SpA). Research biology has shed light on joint destruction that occurs RA peripheral SpA. However, understanding mechanisms behind seen axial SpA been challenging. Mouse models have used gain an key signaling cytokines cells regulating inflammation these diseases. Biologic therapies directed against targets developed control both effects bone. Although biologic improve SpA, leading a decrease pain improving quality life for patients, long-term such must also be evaluated by assessing their impact structural progression. Inhibition radiographic progression easier demonstrate than Here, we discuss similarities differences among as they pertain
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