Carbapenem resistance and mortality in patients with Acinetobacter baumannii infection: systematic review and meta‐analysis

摘要: Acinetobacter baumannii has emerged as a major cause of healthcare-associated infections. Controversy exists to whether antimicrobial resistance increases the risk mortality. We conducted systematic review and meta-analysis examine this association. searched MEDLINE EMBASE databases up May 2013 identify studies comparing mortality in patients with carbapenem-resistant A. (CRAB) vs. carbapenem-susceptible (CSAB). A random-effects model was used pool Odds Ratios (OR). Heterogeneity examined using I(2). included 16 observational studies. There were 850 reported deaths (33%) among 2546 patients. Patients CRAB had significantly higher than CSAB pooled analysis crude effect estimates (crude OR = 2.22; 95% CI 1.66, 2.98), although substantial heterogeneity evident (heterogeneity I(2) 55%). The association remained significant adjusted 10 Studies that compared more likely have severe underlying illness also receive inappropriate empirical treatment, which Our study suggests carbapenem may increase infection. However, cautious interpretation is required because residual confounding factors inadequate sample size most