Dupilumab for the treatment of atopic dermatitis: A clinical trial review.
作者： Sean McGregor , Michael E Farhangian , Steven R Feldman
DOI: 10.1517/14712598.2015.1076388
关键词:
摘要: Introduction: Current treatment options for moderate-to-severe atopic dermatitis (AD) are limited and have potentially dangerous side effects. Dupilumab is a novel monoclonal antibody that was recently studied in adult patients with AD. inhibits interleukin-4 (IL-4) interleukin-13 (IL-13) signaling previously found to be effective asthma. Considering both AD asthma Th2 cell-mediated inflammatory processes, it reasonable suspect dupilumab would beneficial AD.`Areas covered: This article review of the one major clinical trial assessed efficacy Its goal provide comparison current modalities expert insight regarding future studies.Expert opinion: The results this study significant therapeutic advancement. shown mean percent change Eczema Area Severity Index score −74% ± 3.6, addition to, statistical...
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