On the mechanism of antithrombotic action of flavonoids.

摘要: Abstract Flavonols (quercetin and rutin) flavanes (cyanidol meciadonol) were studied for their effect on non-enzymatic lipid peroxidation, lipoxygenase cyclo-oxygenase activities, binding to albumin platelet membranes. These biochemical properties of four flavonoids compared with respect antithrombotic action in vivo efficacy at influencing the platelet-endothelium interaction vitro . All inhibited ascorbate-stimulated formation malondialdehyde by boiled rat liver microsomes > rutin ≈ cyanidol activity meciadonol whereas only flavonols, but not flavanes, stimulated bound The same two flavonols dispersed thrombi which adhering rabbit aortic endothelium ( ec 50 quercetin was 80 nM 500 nM) prevented platelets from aggregation over blood-superfused collagen strip ed 5 nmol/kg 33 i.V.). Cyanidol effective as anti-thrombotic agents. It is concluded that activated vascular generate peroxides oxygen-free radicals inhibit endothelial biosynthesis prostacyclin destroy endothelium-derived relaxing factor (EDRF). are because they selectively mural owing free radical scavenging resuscitate EDRF. Thus, release thrombolytic vasoprotective mediators these segments covered a carpet aggregating platelets.