Rho family proteins: coordinating cell responses
作者： Anne J. Ridley
DOI: 10.1016/S0962-8924(01)02153-5
关键词:
摘要: Rho GTPases hit the headlines several times in 1990-1992: proteins regulating their GTP-GDP cycle were identified and they found to be key signal transducers, mediating growth factor-induced changes actin cytoskeleton activating phagocyte NADPH oxidase. Since then, have been implicated numerous cellular processes, from cell migration survival, transcriptional regulation vesicle trafficking. An explanation for why affect so many aspects of behavior might lie ability interact with a number downstream targets, that can coordinately activate molecular processes required particular response.
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