Occupational socioeconomic risk associations for head and neck cancer in Europe and South America: individual participant data analysis of pooled case–control studies within the INHANCE Consortium

摘要: Background: The association between socioeconomic disadvantage (low education and/or income) and head neck cancer is well established, with smoking alcohol consumption explaining up to three-quarters of the risk. We aimed investigate nature explanations for risk associated occupational prestige (a perceptual measure psychosocial status), position manual-work experience, assess potential explanatory role exposures. Methods: Pooled analysis included 5818 patients (and 7326 control participants) from five studies in Europe South America. Lifetime job histories were coded to: (1) social prestige—Treiman’s Standard International Occupational Prestige Scale (SIOPS); (2) position—International Socio-Economic Index (ISEI); (3) manual/non-manual jobs. Results: For longest held job, adjusting smoking, occupation, increased estimates observed low SIOPS OR=1.88 (95% CI: 1.64 2.17), ISEI OR=1.74 1.51 1.99) manual occupations OR=1.49 1.35 1.64). Following mutual adjustment by exposures, remained OR=1.59 1.30 1.94). Conclusions: These findings indicate that prestige, work are cancer, such risks only partly explained exposures. Perceptual status (SIOPS) appears be strongest factor, relative work.