Let-7i-5p regulation of cell morphology and migration through distinct signaling pathways in normal and pathogenic fibroblasts from urethra
作者： Kaile Zhang , Jun Chen , Shukui Zhou , Ranxin Yang , Ying Wang
DOI: 10.1101/330332
关键词:
摘要: Pelvic fracture urethral distraction defects (PFUDD) is a common disease that could severely affect patients' life quality, yet little known about the molecular mechanism associated with pathogenic fibrosis in PFUDD. In this study, we found let-7i-5p regulate different cellular events normal and fibroblasts through three distinct signaling pathways. Interestingly, those regulations are compromised during translation from mRNA to protein, partially based on status of fibroblasts. By analyzing its function, conclude plays an essential role regulating cell shape tissue elasticity, migration, morphology cytoskeleton, serve as potential target for clinical treatment stricture patients.
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