Actions of excitatory amino acids and kynurenic acid in the primate hippocampus: A preliminary study
作者： T.W. Stone , M.N. Perkins
DOI: 10.1016/0304-3940(84)90184-8
关键词:
摘要: Orthodromic evoked potentials of CA1 pyramidal cells were studied in superfused slices marmoset hippocampus. N-methylaspartate, quinolinic acid and quisqualic depressed the responses, but only former two compounds appeared to be antagonized by 2-amino-5-phosphonovalerate. Kynurenic also reduced orthodromic responses had no effect on antidromic potentials, blocking action therefore probably resulting from an interference with synaptic transmission. The study reveals receptors for quisqualate, quinolinate kynurenic primate hippocampus broadly comparable those previously non-primate vertebrates.
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sci-hub.se 参考文章(21)
L Fagni, M Baudry, G Lynch, Classification and properties of acidic amino acid receptors in hippocampus. I. Electrophysiological studies of an apparent desensitization and interactions with drugs which block transmission. The Journal of Neuroscience. ,vol. 3, pp. 1538- 1546 ,(1983) , 10.1523/JNEUROSCI.03-08-01538.1983
M.N. Perkins, T.W. Stone, J.F. Collins, K. Curry, Phosphonate analogues of carboxylic acids as aminoacid antagonists on rat cortical neurones. Neuroscience Letters. ,vol. 23, pp. 333- 336 ,(1981) , 10.1016/0304-3940(81)90021-5
M.N. Ferkins, J.F. Collins, T.W. Stone, Isomers of 2-amino-7-phosphonoheptanoic acid as antagonists of neuronal excitants. Neuroscience Letters. ,vol. 32, pp. 65- 68 ,(1982) , 10.1016/0304-3940(82)90230-0
J. Davies, A.A. Francis, A.W. Jones, J.C. Watkins, 2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation Neuroscience Letters. ,vol. 21, pp. 77- 81 ,(1981) , 10.1016/0304-3940(81)90061-6
M.N. Perkins, T.W. Stone, An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid Brain Research. ,vol. 247, pp. 184- 187 ,(1982) , 10.1016/0006-8993(82)91048-4
Thomas V. Dunwiddie, Anthony S. Basile, Michael R. Palmer, Electrophysiological responses to adenosine analogs in rat hippocampus and cerebellum: Evidence for mediation by adenosine receptors of the A1 subtype Life Sciences. ,vol. 34, pp. 37- 47 ,(1984) , 10.1016/0024-3205(84)90328-X
H. McLennan, Receptors for the excitatory amino acids in the mammalian central nervous system Progress in Neurobiology. ,vol. 20, pp. 251- 271 ,(1983) , 10.1016/0301-0082(83)90004-7
F. Moroni, G. Lombardi, V. Carlà, G. Moneti, The excitotoxin quinolinic acid is present and unevenly distributed in the rat brain. Brain Research. ,vol. 295, pp. 352- 355 ,(1984) , 10.1016/0006-8993(84)90984-3
J. Lehmann, P. Schaefer, J.W. Ferkany, J.T. Coyle, Quinolinic acid evokes [3H]acetylcholine release in striatal slices: mediation by NMDA-type excitatory amino acid receptors. European Journal of Pharmacology. ,vol. 96, pp. 111- 115 ,(1983) , 10.1016/0014-2999(83)90536-8
E. M. Gál, A. D. Sherman, SYNTHESIS AND METABOLISM OF l‐KYNURENINE IN RAT BRAIN Journal of Neurochemistry. ,vol. 30, pp. 607- 613 ,(1978) , 10.1111/J.1471-4159.1978.TB07815.X