Acute phase reactants and clinical stages in multiple myeloma.

摘要: Serum levels of seven specific proteins mostly acute phase reactants (APR) have been studied (transferrin, alpha 2-macroglobulin, 1-antitrypsin, haptoglobin, C3, ceruloplasmin, orosomucoid) in 14 healthy subjects and 55 patients with multiple myeloma. The 2-macroglobulin transferrin are significantly decreased the myeloma group compared controls whereas remaining under study elevated, only orosomucoid ceruloplasmin. APR IgG3 myelomas seem to show differences from those IgG1 IgG2 subclasses negatively changed being lower, positive higher In IgA myeloma, however, haptoglobin 1-antitrypsin found spite APR. Transferrin serum level can be included as a new parameter regression equations for calculation cell mass.