Changes in Contractile Properties in Hypertrophic Rat Urinary Bladder

作者: Anders Mattiasson , Bengt Uvelius

DOI: 10.1016/S0022-5347(17)53503-X

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摘要: AbstractHypertrophy was induced in female rat urinary bladders by partial obstruction of the urethra. After 6 weeks bladder weight had increased almost 7-fold compared to matched controls. At this stage animals were anesthetized and pelvic nerves stimulated bilaterally at different volumes. Isovolumetric pressures measured means a catheter inserted via For control (C) maximum active pressure (104 ± 11cm. H2O, n = 5) attained with 0.10ml. content. volumes above rapid progressive decrease noted. hypertrophic (H) (92 14cm. 6) reached 0.50ml. Further filling decreased only slightly. By use law Laplace volume-active relations transformed radius-force curves. The stress similar for C H bladders. relation shifted right curve (optimum ra...

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