NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells.

摘要: // Yi Zhu 1, * , Minmin Shi 2, Hao Chen 2 Jiangning Gu 1 Jiaqiang Zhang Baiyong Shen Xiaxing Deng Junjie Xie Xi Zhan Chenghong Peng Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School Medicine, Shanghai, P.R. China Research Institute Digestive These authors have contributed equally to this work Correspondence to: Chen, e-mail: haochendr@126.com Peng, chhpeng@188.com Keywords: pancreatic ductal adenocarcinoma, NPM1, FBP1, warburg effect Received: March 30, 2015      Accepted: May 23, Published: June 05, 2015 ABSTRACT The nucleophosmin ( NPM1 ) activates cancer development and progression in many malignant tumors. However, the regulatory role underlying mechanisms are unknown. In study, we showed that was up-regulated PDAC, which indicated a poor prognosis. We also identified could stimulate aerobic glycolysis repress fructose-1, 6-bisphosphatase FBP1 cells. Restoring expression partially reversed tumor-promoting effects while loss PDAC tissues indicative poorer sum, promotes tumor patients with by inhibiting FBP1.