Incidence of Severe Malaria Syndromes and Status of Immune Responses among Khat Chewer Malaria Patients in Ethiopia

摘要: Although more emphasis has been given to the genetic and environmental factors that determine host vulnerability malaria, other might have a crucial role in burdening disease not evaluated yet. Therefore, this study was designed assess effect of khat chewing on incidence severe malaria syndromes immune responses during infection an area where two problems co-exist. Clinical, physical, demographic, hematological, biochemical immunological data were collected from Plasmodium falciparum mono-infected patients (age ≥ 10 years) seeking medication Halaba Kulito Jimma Health Centers. In addition, incidences symptoms assessed. The analyzed using SPSS (version 20) software. Prevalence current chewer 57.38% (95%CI =53-61.56%). Malaria such as hyperpyrexia, prostration hyperparasitemia significantly lower (P 0.05), IgG3 antibody higher (P<0.001) among patients. Moreover, IgM, IgG, IgG1and antibodies had significant negative association with parasite burden clinical manifestations symptoms, but anemia hypoglycemia. Additionally, increment (P<0.05) CD4+ T-lymphocyte population observed users. Khat be important risk factor for some complications. Nevertheless, it can enhance induction humoral response infection. This calls further investigation or antigen-specifc protective immunity analysis cytokines released upon chewers.