Lutein and Oxidative Stress-Mediated Retinal Neurodegeneration in Diabetes

摘要: Although many details remain elusive, recent progress in molecular biology has elucidated the underlying mechanisms of disease pathogeneses, including some fundamental concepts. One such concept is that oxidative stress involved age-related progression diseases, as observed diabetic complications and neurodegenerative diseases. Concordantly, accumulates with time, can eventually overcome biological defense systems. Therefore, diseases might be prevented or slowed by suppressing stress. Here we focus on lutein, a plant-derived carotenoid food factor act an antioxidant mammalian retina. In animal model diabetes, continuous intake lutein suppresses diabetes-related reduction synaptophysin protein brain-derived neurotrophic retina, subsequent visual function impairment. This mechanism overlaps renin-angiotensin system. review involvement diabetes-associated retinal neurodegeneration discuss lutein’s neuroprotective effects.