Research in human genetics: the tension between doing no harm and personal autonomy.

摘要: The physician-patient relationship was governed for centuries by the ethical principle of beneficence and physician's dedication to doing no harm. This structure shifted, however, personal autonomy as medical surgical knowledge expanded patients, rather than physicians, became locus decision-making authority. In biomedical research in United States, professional remained dominant until a spectrum doubtful practices made public 1970s thereafter. Over past three decades, state federal governments have instituted regulations that provide increased protections human subjects, although results are rarely shared with subjects because provisional nature unconfirmed laboratory results. Now, genetics researchers others suggest may well an interest present future results, even though provisional. These issues presently under discussion eventually open new possibilities sharing information who wish be informed.