Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer

作者: Jay Lusk , Vanessa Lam , Nicholas Tolwinski

DOI: 10.3390/CANCERS9020016

关键词:

摘要: EGF signaling is a well-known oncogenic pathway in animals. It also key developmental regulating terminal and dorsal-ventral patterning along with many other aspects of embryogenesis. In this review, we focus on the diverse roles for Drosophila We review existing body evidence concerning embryogenesis focusing current uncertainties field areas future study. This provides foundation utilizing model system research into effects cancer.

参考文章(88)
R. Marais, Y. Light, H.F. Paterson, C.J. Marshall, Ras recruits Raf‐1 to the plasma membrane for activation by tyrosine phosphorylation. The EMBO Journal. ,vol. 14, pp. 3136- 3145 ,(1995) , 10.1002/J.1460-2075.1995.TB07316.X
W.H. Biggs, K.H. Zavitz, B. Dickson, A. van der Straten, D. Brunner, E. Hafen, S.L. Zipursky, The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway. The EMBO Journal. ,vol. 13, pp. 1628- 1635 ,(1994) , 10.1002/J.1460-2075.1994.TB06426.X
Bomyi Lim, Carmeline J. Dsilva, Thomas J. Levario, Hang Lu, Trudi Schüpbach, Ioannis G. Kevrekidis, Stanislav Y. Shvartsman, Dynamics of Inductive ERK Signaling in the Drosophila Embryo Current Biology. ,vol. 25, pp. 1784- 1790 ,(2015) , 10.1016/J.CUB.2015.05.039
Keuk Il Jung, Sang-Hak Jeon, Sang Hee Kim, Se Young Kim, Dpp represses eagle expression at short-range, but can repress its expression at a long-range via EGFR signal repression. Molecules and Cells. ,vol. 26, pp. 576- 582 ,(2008)
FranÇois Payre, Alain Vincent, Sebastien Carreno, ovo/svb integrates Wingless and DER pathways to control epidermis differentiation Nature. ,vol. 400, pp. 271- 275 ,(1999) , 10.1038/22330
Takashi Adachi-Yamada, Kenji Irie, Young-Mi Lim, Kunihiro Matsumoto, Yoshimi Nishi, Yoshihiro H. Inoue, Mami Hata, Yasuyoshi Nishida, Leo Tsuda, Dominant mutations of Drosophila MAP kinase kinase and their activities in Drosophila and yeast MAP kinase cascades. Genetics. ,vol. 146, pp. 263- 273 ,(1997) , 10.1093/GENETICS/146.1.263
Masako Tamada, Jennifer A. Zallen, Square Cell Packing in the Drosophila Embryo through Spatiotemporally Regulated EGF Receptor Signaling Developmental Cell. ,vol. 35, pp. 151- 161 ,(2015) , 10.1016/J.DEVCEL.2015.09.015
C Klämbt, A Klaes, H Scholz, J Deatrick, Genetic dissection of pointed, a Drosophila gene encoding two ETS-related proteins. Genetics. ,vol. 135, pp. 455- 468 ,(1993) , 10.1093/GENETICS/135.2.455
Corey S. Goodman, Alex L. Kolodkin, Utpal Banerjee, David M. Lin, Amanda T. Pickup, Characterization of Star and its interactions with sevenless and EGF receptor during photoreceptor cell development in Drosophila. Development. ,vol. 120, pp. 1731- 1745 ,(1994) , 10.1242/DEV.120.7.1731