A practical and scalable process to selectively monofunctionalize water-soluble α,ω-diols
作者： Quanxuan Zhang , Hong Ren , Gregory L. Baker
DOI: 10.1016/J.TETLET.2014.04.066
关键词:
摘要: Abstract A practical protocol for rapid and scalable synthesis of monofunctionalized α,ω-diols using a simple inexpensive THP ether protection/deprotection strategy was described. Use DHP source ease to remove excess water-soluble after deprotection render the process scale-friendly without need column chromatographic separation. The application present method also illustrated in preparation heterobifunctional diols well-defined extended oligo(ethylene glycol).
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