Monodisperse engineered PEGs for bio-related applications

摘要: The importance of monodisperse poly(ethylene glycols) (PEGs) and their derivatives is rapidly increasing. Focusing on the merits heterobifunctional PEGs, we developed a chromatography-free procedure for preparation monotosylated PEGs. This technique enables 8- to 16-mers in relatively large quantities, with good yields purities, facilitates investigation PEG-based functional molecules. For example, synthesized structured PEGs consisting polyols, which had specific two-dimensional shapes. These exhibited unique properties aqueous environments; triangular molecule dehydrated at lower temperature than linear compounds similar molecular weight could thus suppress aggregation proteins high temperatures. We also found that introduction an aromatic group into PEG skeleton lowered dehydration temperature, decreased critical solution temperatures (LCSTs). Recent achievements development engineered glycol)s will be highlighted this review. A allowed quantities purities molecules such as can It was temperature.