Regioselective synthesis of 1,3,5-triaryl-4-alkylpyrazoles: novel ligands for the estrogen receptor.
作者： Ying R. Huang , John A. Katzenellenbogen
DOI: 10.1021/OL0062650
关键词:
摘要: A regioselective synthesis of 4-alkyl-1,3,5-triarylpyrazoles has been developed for the preparation of unsymmetrically substituted systems of interest as ligands for the estrogen receptor. …
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sci-hub.se 参考文章(10)
Shaun R. Stauffer, John A. Katzenellenbogen, Solid-Phase Synthesis of Tetrasubstituted Pyrazoles, Novel Ligands for the Estrogen Receptor ACS Combinatorial Science. ,vol. 2, pp. 318- 329 ,(2000) , 10.1021/CC0000040
Frank B. Kaufman, Edward M. Engler, Solid-state spectroelectrochemistry of crosslinked donor bound polymer films Journal of the American Chemical Society. ,vol. 101, pp. 547- 549 ,(1979) , 10.1021/JA00497A009
Brian E Fink, Deborah S Mortensen, Shaun R Stauffer, Zachary D Aron, John A Katzenellenbogen, Novel structural templates for estrogen-receptor ligands and prospects for combinatorial synthesis of estrogens Chemistry & Biology. ,vol. 6, pp. 205- 219 ,(1999) , 10.1016/S1074-5521(99)80037-4
Andreas L. Marzinzik, Eduard R. Felder, Key Intermediates in Combinatorial Chemistry: Access to Various Heterocycles from alpha,beta-Unsaturated Ketones on the Solid Phase. Journal of Organic Chemistry. ,vol. 63, pp. 723- 727 ,(1998) , 10.1021/JO971620U
Gregory M. Anstead, Kathryn E. Carlson, John A. Katzenellenbogen, The estradiol pharmacophore: Ligand structure-estrogen receptor binding affinity relationships and a model for the receptor binding site Steroids. ,vol. 62, pp. 268- 303 ,(1997) , 10.1016/S0039-128X(96)00242-5
Gregory M. Anstead, Chad S. Peterson, John A. Katzenellenbogen, Hydroxylated 2,3-diarylindenes: Synthesis, estrogen receptor binding affinity, and binding orientation considerations Journal of Steroid Biochemistry. ,vol. 33, pp. 877- 887 ,(1989) , 10.1016/0022-4731(89)90235-5
Alfred Hassner, Malvin J. Michelson, N.m.r. Spectra and Stereoisomerism in Pyrazolines Journal of Organic Chemistry. ,vol. 27, pp. 3974- 3976 ,(1962) , 10.1021/JO01058A052
L. B. Overacre, R. A. Magarian, K. L. Meyer, S. Singh, The medicinal chemistry of nonsteroidal antiestrogens: a review Current Medicinal Chemistry. ,vol. 1, pp. 61- 104 ,(1994)
Xiao-jun Wang, Jonathan Tan, Karl Grozinger, Cross-coupling of 1-aryl-5-bromopyrazoles: regioselective synthesis of 3,5-disubstituted 1-arylpyrazoles Tetrahedron Letters. ,vol. 41, pp. 4713- 4716 ,(2000) , 10.1016/S0040-4039(00)00704-8
J A Dodge, T A Grese, Selective estrogen receptor modulators (SERMs). Current Pharmaceutical Design. ,vol. 4, pp. 71- 92 ,(1998)