Heterocyclic pyrazole-carboxamidesas P2Y12 antagonists
作者： Markus Kohlmann , Gerhard Hessler , Gernot Zech , Marc Nazaré , Melitta Just
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摘要: The present invention relates to compounds of the formula I, wherein R1; R2; Z; A; B; D; Q; J; V; G and M have meanings indicated in claims. I are valuable pharmacologically active compounds. They exhibit a strong anti-aggregating effect on platelets thus an anti-thrombotic suitable, e.g., for therapy prophylaxis cardio-vascular disorders like thromboembolic diseases or restenoses. reversible antagonists platelet ADP receptor P2Y12, can general be applied conditions which undesired activation P2Y12 is cure prevention inhibition intended. furthermore processes preparation their use, particular as ingredients pharmaceuticals, pharmaceutical preparations comprising them.
lens.org 参考文章(91)
Oyo Mitsunobu, The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products Synthesis. ,vol. 1981, pp. 1- 28 ,(1981) , 10.1055/S-1981-29317
J. F. W. McOmie, Protective Groups in Organic Chemistry ,(2012)
J. Fraser Mustard, Raelene L. Kinlough-Rathbone, Marian A. Packham, Isolation of human platelets from plasma by centrifugation and washing. Methods in Enzymology. ,vol. 169, pp. 3- 11 ,(1989) , 10.1016/0076-6879(89)69045-3
HISAO OCHI, TADASHI MIYASAKA, Synthesis of 2-Substituted 2, 6-Dihydro-3-hydroxy-7H-pyrazolo [4, 3-d] pyrimidin-7-ones Chemical & Pharmaceutical Bulletin. ,vol. 31, pp. 1228- 1234 ,(1983) , 10.1248/CPB.31.1228
Michael B. Smith, March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure ,(2007)
Metal-catalyzed cross-coupling reactions Wiley-VCH. ,(2004) , 10.1002/9783527619535
Benjamin H. Evert, Gain selection technique ,(1995)
Brad O. Buckman, Shendong Yuan, Judi A. Bryant, Raju Mohan, Guo Ping Wei, Wei Xu, Michael M. Morrissey, Imadul Islam, Platelet adenosine diphosphate receptor antagonists ,(2004)
Bohdan Waszkowycz, Christopher Neil Farthing, Sarah Elizabeth Lively, Martin James Harrison, Keith Michael Johnson, Serine protease inhibitors United States Patent and Trademark Office. ,(2001)
Joel C. Barrish, Zhengxiang Gu, Natesan Murugesan, Richard A. Morrison, Isoxazolyl endothelin antagonists ,(1998)