Hydroxyakalone, a Novel Xanthine Oxidase Inhibitor Produced by a Marine Bacterium, Agrobacterium aurantiacum
作者： HITOSHI IZUMIDA , KYOKO ADACHI , AKIRA MIHARA , TOHRU YASUZAWA , HIROSHI SANO
DOI: 10.7164/ANTIBIOTICS.50.916
关键词:
摘要: A new xanthine oxidase inhibitor named hydroxyakalone was isolated from the culture broth of a marine bacterium Agrobacterium aurantiacum N-81106. Structure determined to be 4-amino-1H-pyrazolo[3, 4-d]pyrimidine-3-one-6-ol by spectral studies and its permethyl derivative. The concentration induce 50% inhibition (IC50) 4.6μM against oxidase.
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