Maternal Restraint Stress Diminishes the Developmental Potential of Oocytes

摘要: Although studies of both humans and animals suggest detrimental effects psychological (restraint) stress on reproduction, reports concerning the direct effect oocyte are few conflicting. In present study, a restraint system that allows mice free intake feed water while restraining their movement was established, maternal competence were examined by observing embryo development in vitro vivo. The results indicated applied to gonadotropin-stimulated unstimulated females during growth maturation increased plasma cortisol level but impaired ovulation developmental potential. Injection also decreased potential stimulated mice. However, whereas reduced follicle-stimulating hormone (FSH) mice, injection did not. Because had received very high doses FSH luteinizing from with equine chorionic gonadotropin injection, suggested acts directly ovary damage oocyte, impairs actions hypothalamic-pituitary-gonadal hypothalamic-pituitary-adrenal axes. exposing cumulus-oocyte complexes (COCs) physiological levels not affect nuclear cytoplasmic vitro. Thus, might have an indirect ovarian tissues other than COCs.