Biaryl piperidines as potent and selective delta opioid receptor ligands
作者： Spiros Liras , Stanton F. McHardy , Martin P. Allen , Barb E. Segelstein , Steven D. Heck
DOI: 10.1016/J.BMCL.2009.11.113
关键词:
摘要: The design and synthesis of novel opiates are reported. Based on the message-address principle a class 4,4- 3,3-biaryl piperidines was designed synthesized. Biological evaluation confirmed that these compounds exhibit high affinity selectivity for delta opioid receptor. Key structure-activity relationships influence affinity, selectivity, functional activity clearance
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