δ-Opioid receptor agonist SNC80 induces peripheral antinociception via activation of ATP-sensitive K+ channels
作者： Daniela F. Pacheco , Igor D.G. Duarte
DOI: 10.1016/J.EJPHAR.2005.02.018
关键词:
摘要: Abstract We investigated the effect of several K + channel blockers on antinociception induced by δ-opioid receptor agonist SNC80 using paw pressure test, in which pain sensitivity is increased an intraplantar injection (2 μg) prostaglandin E 2 (PGE ). Administration (20, 40 and 80 μg/paw) caused a decrease hyperalgesia PGE , dose-dependent manner. The possibility higher dose (80 causing central or systemic was excluded since administration drug into contralateral did not elicit right paw. Specific ATP-sensitive channels, glibenclamide tolbutamide (40, 160 μg/paw), antagonized peripheral μg). On other hand, charybdotoxin large-conductance blocker Ca 2+ -activated dequalinium (50 small conductance selective modify SNC80. This also remained unaffected voltage-dependent tetraethylammonium (30 4-aminopyridine (10 non-specific blocker, cesium (500 μg/paw). study provides evidence that antinociceptive result from activation channels are involved.
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