P2-01-04: The Post-Partum Diagnosis of Pregnancy Associated Breast Cancer Confers an Increased Risk for Metastasis without Increased Incidence of Poorer Prognosis Biologic Subtype.

摘要: Background: All women who complete a childbirth have an increased risk for the subsequent breast cancer regardless of age at their first birth. In younger women, this period truncates 10 years later and pregnancy then becomes protective, whereas in older mothers persists. Moreover, cancers diagnosed to recent metastasis death. However much existing data is confounded by inclusion cases during pregnancy. Hypothesis: Our preclinical models associated (PABC) has identified “involution hypothesis”, where normal physiologic post-partum involution pregnancy-related event promotional growth, invasion metastasis. We performed retrospective cohort study, restricted postpartum PABC controls, fully characterize biologic subtype known predictors Also we identify if specific higher non-PABC, as predicted our animal model studies. Methods: 527 45 or from 1981–2011. Pregnancy status was medical records defined nulliparous (n=107), (up 5 last childbirth, n=114), Later Parous (>10 post-partum, n=239). Clinicopathologic characteristics were obtained pathology records. Outcomes through University Colorado Tumor Registrar. Hazard ratios metastatic recurrence groups analyzed using Cox Proportional Hazards Model time standard Kaplan Meier curves. Results: Compared cases, more frequently Stage IV(11.4% v. 4.9%), T3 tumor size(17.3% 13.1%), poorly differentiated(56.6% 49.0%), lobular histology(4.5% v.1.0%), with lymphovascular invasion(30.4% 24.5%) involved lymphnodes(57.6% 48.6%). No differences seen between Luminal A, B, Her 2 Triple Negative subtypes. Average follow-up 3.4 nulliparous, 3.5 4.6 Parous. Survival analysis revealed cumulative 5-year free probability 80.6% 68.5% 80.5% had greater than three times (HR 3.29, 95% CI: 1.25−8.63). significant difference compared observed (HR: 1.079, 0.46−2.55). Conclusion: Post-partum characterized stage diagnosis but without enrichment poorer prognosis Post-Partum within five diagnosis, overall 3.29 recurrence. These support hypothesis that window, role naturally occurring involution, may be previously models. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P2-01-04.