SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer' Disease: The Role of the Immune System in Clearance of Aβ from the Brain

作者: Delphine Boche , James A.R. Nicoll

DOI: 10.1111/J.1750-3639.2008.00134.X

关键词:

摘要: … disappointing results of prospective clinical trials of anti-inflammatory agents and, second, the observation that microglia can clear plaques in AD following Aβ immunization. Although …

参考文章(126)
Donata M. Paresce, Haeyong Chung, Frederick R. Maxfield, Slow Degradation of Aggregates of the Alzheimer’s Disease Amyloid β-Protein by Microglial Cells Journal of Biological Chemistry. ,vol. 272, pp. 29390- 29397 ,(1997) , 10.1074/JBC.272.46.29390
M. HÜLL, M. BERGER, B. VOLK, J. BAUER, Occurrence of Interleukin-6 in Cortical Plaques of Alzheimer's Disease Patients May Precede Transformation of Diffuse into Neuritic Plaquesa Annals of the New York Academy of Sciences. ,vol. 777, pp. 205- 212 ,(1996) , 10.1111/J.1749-6632.1996.TB34420.X
W.S.T. Griffin, J.G. Sheng, M.C. Royston, S.M. Gentleman, J.E. McKenzie, D.I. Graham, G.W. Roberts, R.E. Mrak, Glial-Neuronal Interactions in Alzheimer's Disease: The Potential Role of a ‘Cytokine Cycle’ in Disease Progression Brain Pathology. ,vol. 8, pp. 65- 72 ,(2006) , 10.1111/J.1750-3639.1998.TB00136.X
Lars Bertram, Matthew B McQueen, Kristina Mullin, Deborah Blacker, Rudolph E Tanzi, Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database Nature Genetics. ,vol. 39, pp. 17- 23 ,(2007) , 10.1038/NG1934
J.-C. Dodart, C. Mathis, K. R. Bales, S. M. Paul, Does my mouse have Alzheimer's disease? Genes, Brain and Behavior. ,vol. 1, pp. 142- 155 ,(2002) , 10.1034/J.1601-183X.2002.10302.X
W. J. Strittmatter, A. M. Saunders, D. Schmechel, M. Pericak-Vance, J. Enghild, G. S. Salvesen, A. D. Roses, Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 1977- 1981 ,(1993) , 10.1073/PNAS.90.5.1977
E. Masliah, L. Hansen, A. Adame, L. Crews, F. Bard, C. Lee, P. Seubert, D. Games, L. Kirby, D. Schenk, Aβ vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease Neurology. ,vol. 64, pp. 129- 131 ,(2005) , 10.1212/01.WNL.0000148590.39911.DF
N. C. Fox, R. S. Black, S. Gilman, M. N. Rossor, S. G. Griffith, L. Jenkins, M. Koller, , Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease. Neurology. ,vol. 64, pp. 1563- 1572 ,(2005) , 10.1212/01.WNL.0000159743.08996.99
Takato Morioka, Audrey N. Kalehua, Wolfgang J. Streit, Characterization of microglial reaction after middle cerebral artery occlusion in rat brain The Journal of Comparative Neurology. ,vol. 327, pp. 123- 132 ,(1993) , 10.1002/CNE.903270110
F. Bard, R. Barbour, C. Cannon, R. Carretto, M. Fox, D. Games, T. Guido, K. Hoenow, K. Hu, K. Johnson-Wood, K. Khan, D. Kholodenko, C. Lee, M. Lee, R. Motter, M. Nguyen, A. Reed, D. Schenk, P. Tang, N. Vasquez, P. Seubert, T. Yednock, Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 2023- 2028 ,(2003) , 10.1073/PNAS.0436286100