Crosstalk between kinases, phosphatases and miRNAs in cancer

摘要: Reversible phosphorylation of proteins, performed by kinases and phosphatases, is the major post translational protein modification in eukaryotic cells. This intracellular event represents a critical regulatory mechanism several signaling pathways can be related to vast array diseases, including cancer. Cancer research has produced increasing evidence that kinase phosphatase activity compromised mutations also miRNA silencing, small non-coding endogenously RNA molecules lead repression. miRNAs are believed target about one-third human mRNAs while single may 200 transcripts simultaneously. Regulation balance been topic intense over last years, spanning topics going as far cancer aggressiveness chemotherapy resistance. By addressing recent studies have shown expression patterns phenotypic signatures cancers how influence cellular processes such apoptosis, cell cycle control, angiogenesis, inflammation DNA repair, we discuss kinases, phosphatases cooperatively act biology.