The relationship between the actions of vitamin D, parathyroid hormone and calcitonin

摘要: The effect of PTH and CT upon hydroxyproline electrolyte excretion, plasma calcium phosphate, balance, the excretion radiocalcium was examined in vitamin D-deficient thyroparathyroidectomized rats. results were compared to those obtained D-fed animals. An increase urinary hydroxyproline, which persisted for many hours, occurred animals approximately 30 h after thyroparathroidectomy, but not seen It suppressed by high infusion. Infusion or increased hydroxyprolinuria even further animls. animals, caused a significant decrease. In both decrease an already positive balance. had similar effects, negative Young injected with45Ca while on diet studied 3 weeks later at time when they developed D-deficiency. When these maintained constant glucose perfusion, relatively specific activity urnary declined only slightly over 28 period. given, total radioactive diminished initially, leading activity. first hormone infusion, then rose gradually became greater than normal during last 4 given with PTH, fell remained below control rate throughout experiment. Specific markedly 2 h, rapidly values levels remainder