Estrogens and polyamines in breast cancer: their profiles and values in disease staging
作者： Seon Hwa Lee , Soon Ok Kim , Hy-De Lee , Bong Chul Chung
DOI: 10.1016/S0304-3835(98)00189-X
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摘要: The urinary concentrations of 16 estrogens and 11 polyamines were quantitatively determined by gas chromatography‐mass spectrometry chromatography with nitrogen-phosphorus detection. Samples from patients stages I‐IV breast cancer (35 cases, aged 27‐65 years) as well age-matched normal female subjects (25 22‐61 tested. Also, the ratios precursor to product metabolite including 16a -OH E1 2-OH E1, which are linked estrogen polyamine biosynthetic pathways, explore enzyme involvement in evaluate potential usefulness these disease staging markers. It was confirmed that major positively associated catechol inversely cancer. N 1 -acSp/Spd E1/2-OH might be a useful dual marker for From variation relative polyamines, it is suggested alteration oxidase (PAO) activity may play an important role development q 1998 Elsevier Science Ireland Ltd. All rights reserved.
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