Biological properties of 16 alpha-hydroxyestrone: implications in estrogen physiology and pathophysiology.
作者： JACK FISHMAN , CHARLES MARTUCCI
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摘要: Metabolism of estradiol in men with cirrhosis and subjects systemic lupus erythematosus results an excessive formation 16±-hydroxyestrone. Examination the biological activity this metabolite showed that it is a potent uterotropic agent exhibits minimal affinity for human sex hormone-binding globulin. These characteristics are consistent hyperestrongenic response to substance, which may be reflected pathology etiology these diseases.
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