Th2 and Th1 Responses: Clear and Hidden Sides of Immunity Against Intestinal Helminths
作者： Alba Cortés , Carla Muñoz-Antoli , J. Guillermo Esteban , Rafael Toledo
关键词:
摘要: Intestinal helminthiases affect millions of people worldwide, mainly in developing regions, where they cause a significant negative impact on human health and socioeconomic growth affected populations. However, intestinal are still among the most neglected tropical diseases. Protective immunity against helminths is associated with development type 2 responses. Nevertheless, some host–intestinal helminth combinations, local Th1 responses initiated, inducing chronicity. The usage helminth–mouse models useful for elucidating mechanisms behind initiation each response. Herein, current knowledge these topics reviewed, paying particular attention to earliest events immune cascade which eventually lead either susceptibility or resistance infection.
sci-hub.se 参考文章(108)
Jinfang Zhu, T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production. Cytokine. ,vol. 75, pp. 14- 24 ,(2015) , 10.1016/J.CYTO.2015.05.010
Ari B. Molofsky, Adam K. Savage, Richard M. Locksley, Interleukin-33 in tissue homeostasis, injury and inflammation Immunity. ,vol. 42, pp. 1005- 1019 ,(2015) , 10.1016/J.IMMUNI.2015.06.006
Mindy Tsai, Michele Grimbaldeston, Stephen J. Galli, Mast Cells and Immunoregulation/Immunomodulation Advances in Experimental Medicine and Biology. ,vol. 716, pp. 186- 211 ,(2011) , 10.1007/978-1-4419-9533-9_11
Lisa M. Connor, Shiau-Choot Tang, Mali Camberis, Graham Le Gros, Franca Ronchese, Helminth-Conditioned Dendritic Cells Prime CD4+ T Cells to IL-4 Production In Vivo The Journal of Immunology. ,vol. 193, pp. 2709- 2717 ,(2014) , 10.4049/JIMMUNOL.1400374
Helena Helmby, Richard K. Grencis, IFN-gamma-independent effects of IL-12 during intestinal nematode infection. Journal of Immunology. ,vol. 171, pp. 3691- 3696 ,(2003) , 10.4049/JIMMUNOL.171.7.3691
K A Smith, K J Filbey, L A Reynolds, J P Hewitson, Y Harcus, L Boon, T Sparwasser, G Hämmerling, R M Maizels, Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths Mucosal Immunology. ,vol. 9, pp. 428- 443 ,(2016) , 10.1038/MI.2015.73
Ari B. Molofsky, Frédéric Van Gool, Hong-Erh Liang, Steven J. Van Dyken, Jesse C. Nussbaum, Jinwoo Lee, Jeffrey A. Bluestone, Richard M. Locksley, InterleuKin-33 And Interferon-Γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation During Immune Perturbation Immunity. ,vol. 43, pp. 161- 174 ,(2015) , 10.1016/J.IMMUNI.2015.05.019
Alba Cortés, Carla Muñoz-Antoli, Carla Martín-Grau, J. Guillermo Esteban, Richard K. Grencis, Rafael Toledo, Differential alterations in the small intestine epithelial cell turnover during acute and chronic infection with Echinostoma caproni (Trematoda) Parasites & Vectors. ,vol. 8, pp. 334- 334 ,(2015) , 10.1186/S13071-015-0948-5
Paul Giacomin, Martha Zakrzewski, John Croese, Xiaopei Su, Javier Sotillo, Leisa McCann, Severine Navarro, Makedonka Mitreva, Lutz Krause, Alex Loukas, Cinzia Cantacessi, Experimental hookworm infection and escalating gluten challenges are associated with increased microbial richness in celiac subjects Scientific Reports. ,vol. 5, pp. 13797- 13797 ,(2015) , 10.1038/SREP13797
Hamida Hammad, Bart N. Lambrecht, Barrier Epithelial Cells and the Control of Type 2 Immunity Immunity. ,vol. 43, pp. 29- 40 ,(2015) , 10.1016/J.IMMUNI.2015.07.007